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KMID : 1129720040210040101
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Korean Journal of Acupuncture
2004 Volume.21 No. 4 p.101 ~ p.115
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The Effects of 120 Hz High Frequency Electroacupuncture on the Gastric Mucosa in Cold-Restraint Stressed Rats
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Jo Mee-Hyeong
Ahn Chang-Beohm
Song Chun-Ho
Yoon Hyun-Min
Kim Cheol-Hong
Jang Kyung-Jeon
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Abstract
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Objective : The present studies investigated the effects of 120 Hz high frequency electroacupuncture (EA) on the stress-induced stomach dysfunction in relation to its effect on the level of stress hormones and gastric mucosal damages. The gastric mucosal injury was induced by cold-restraint stress and two acupoints corresponding to Zusanli and Sanyinjiao in man were used.
Methods : Cold-restraint stress produced typical gastric lesions in all rats of the stressed groups, but the number of ulcers as well as the mean ulcer diameter were reduced by 120 Hz EA pre-treatment.
Results : The degranulation value of gastric mast cell was significantly higher in cold-restrained rats than in control ones. However, with the significant reduction of degranulation values of gastric mast cells in EA pre-treated rats compared with cold-restrained rats. Cold-restarint stress induced an elevated mRNA expression of pro-inflammatory gene such as cyclooxygenases-2 and tumor necrosis factor , but these expression were down-regulated in EA pre-treated rats. Immunohistochemical analysis showed that while the and immunorection in the surface epithelium of the stomach tended to increase, both reactions in the EA pre-treated rats showed similar pattern as observed in controls.
Conclusion : These results suggest that 120 Hz EA may act as a therapeutical means for gastric mucosal damages through an activation of pituitary adrenal system. It could be concluded that 120 Hz high frequency electroaucupuncture affords a good protective potential against stress-induced gastrointestinal dysfunction.
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KEYWORD
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Electroacupuncture, Gastric Mucosa, Cold-Restraint
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