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KMID : 1129720050220020089
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Korean Journal of Acupuncture
2005 Volume.22 No. 2 p.89 ~ p.105
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A Study on the Effects of Herbal-acupuncture with Notopterygii Radix solution at ST36 on CIA in Mice
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Park Hyun-Sun
Yim Yun-Kyoung
Lee Byung-Ryul
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Abstract
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Objective & Methods : This study is performed to observe the effect of Herbal-acupuncture with Notopterygii Radix Herbal-Acupuncture Solution(NR-HAS) at Joksamni(ST36) on Collagen II-induced arthritis (CIA) in DBA/1J mice.
Result : 1. The highest survival rate of mice lung fibroblasts were measured in the 1% NR-HAS, and the expression of in synovial cells were significantly decreased in the 1% and 10% NR-HAS. 2. The incidence of arthritis and the spleen weight were significantly decreased by Notopterygii Radix Herbal-acupuncture(NR-HA) at ST36. 3. The levels of IL-6, , IgG, IgM, anti-collagen II in serum of CIA mice were significantly decreased by NR-HA at ST36. 4. In histology, the cartilage destruction and synovial cell proliferation were decreased by NR-HA at ST36, and the collagen fiber expressions in the NR-HA I II groups were similar with that of the normal group. 5. In lymph node, the expression ratios of cell and cell in the NR-HA I II groups were similarly maintained as those in the normal group. 6. In lymph node, cells and cells were decreased by NR-HA at ST36. 7. In the articular joint, cells were decreased by NR-HA at ST36. 8. NR-HA at ST36 did not make a considerable difference in DBA/1J mice without CIA 9. Throughout the overall experimental result, NR-HA I group showed more predominant effect than the NR-HA II group.
Conclusion : These results suggest that NR-HA at ST36 has an effect to control synovial cell proliferation and cartilage destruction in rheumatoid arthritis, as well as prophylaxis is important to treat rheumatoid arthritis in clinic.
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KEYWORD
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Notopterygii Radix, Herbal-Acupuncture, ST36, Collagen-induced arthritis(CIA)
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