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KMID : 1129720050220030063
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Korean Journal of Acupuncture
2005 Volume.22 No. 3 p.63 ~ p.81
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Effects of Folium Artemisiae Argyi’ Herbal Acupuncture of on Transient Forebrain Ischemic Injury in Rats
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Jang Jin-Yo
Kim Jae-Hyo
Park Sung-Sub
Park Gui-Jong
Kim Kyung-Sik
Sohn In-Chul
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Abstract
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Herbal acupuncture has been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. The main characteristics of herbal acupuncture are a combination of acupuncture and herbal medicine. It was not well known the therapeutic effect and the mechanism of herbal acupuncture on transient forebrain ischemic injury, although it has been used frequently in clinics. In this study, neuroprotective effects of folium artemisiae argyi (艾葉)’ herbal acupuncture on the (Taechung) on the transient forebrain ischemia were investigated in Sprague-Dawely rats. Expressions of cFos, FosB and BDNF protein in the hippocampus and cortex were observed at 2 hrs and 48 hrs after transient forebrain ischemia by immunohistochemistry and ELISA technique. Expression of cFos protein was increased slightly in the hippocampus and cortex at 2 hrs after transient forebrain ischemia, but FosB protein was increased highly comparing to cFos protein. However, pretreatment with folium artemisiae argyi’ herbal acupuncture on significantly increased expression of cFos protein and significantly decreased expression of FosB protein compared to control group. These features were observed in the motor cortex and retrosplenial granular cortex as well as the hippocampus. Also, pretreatment with folium artemisiae argyi’ herbal acupuncture on significantly increased the expression of BDNF protein in the hippocampus ( extracted by water, extracted by moxa tar)and the cortex ( extracted by water, extracted by moxa tar) compared to the hippocampus and the cortex in control group at 48 hrs after transient forebrain ischemia. These results suggest that pretreatment with folium artemisiae argyi’herbal acupuncture on has neuroprotective effect on transient forebrain ischemia and the herbal acupunture on may be related to antioxidative function of folium artemisiae argyi.
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KEYWORD
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Taechung, folium artemisiae argyi, herbal acupuncture, transient forebrain ischemic injury
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