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KMID : 1129720050220040091
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Korean Journal of Acupuncture
2005 Volume.22 No. 4 p.91 ~ p.107
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The Effects of Eriobotryae Folium Herbal-acupuncture at ST36 on ovalbumin-induced asthma in C57BL mouse
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Jung Ju-Youl
Yim Yun-Kyoung
Lee Hyun
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Abstract
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To study the effects of EF(Eriobotryae Folium) herbal acupuncture on asthma, we injected EF-HAS into Jok-samni(ST36) of C57BL/6 mice
Objective : The aim of this study was to investigate the effect of EF-HA(herbal acupuncture) at ST36 on ovalbumin-induced asthma in mice
Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). Experimental groups were treated with concentrations(1%) of EF-HA at Jok-samni(ST36) for the later 8 weeks(3times/week).
Result : 1. The weight and total cells of lung of the mice group treated with EF-HA decreased significantly compared with that of Control group. 2. Total Leukocytes and Eosinophils in BALF of the mice group treated with EF-HA decreased significantly compared with those of Control group. 3. The sticking of collagen on histological analysis of lung sections, the mice group treated with EF-HA decreased significantly compared with those of Control group. 4. The concentration of IgE, IL-4, IL-5 in BALF of the mice group treated with EF-HA decreased significantly compared with those of Control group. 5. The concentration of IL-4, IL-5, IL-13 in Serum of the mice group treated with EF-HA decreased significantly compared with those of Control group. 6. The number of cells in the lungs of the mice group treated with EF-HA decreased significantly compared with those of Control group. 7. The cytokine’s manifestation of mRNA of the mice group treated with EF-HA with RT-PCR decreased significantly compared with that of Control group.
Conclusion : We conclude that EF-HA is effective on OVA-induced asthma of C57BL/6 mouse.
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KEYWORD
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OVA-induced asthma, Eriobotryae Folium, HA(herbal acupuncture)
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