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KMID : 1129720060230020155
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Korean Journal of Acupuncture
2006 Volume.23 No. 2 p.155 ~ p.166
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The Effect of Plantaginis Semen on CCI4 Induced Hepatoxicity in Rats
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Kwon Seon-Ho
Kim Cheol-Hong
Youn Hyoun-Min
Jang Kyung-Jeon
Ahn Chang-Beohm
Kim Hoon
Song Chun-Ho
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Abstract
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Objectives: This study was undertaken to determine if Plantaginis Semen(PS) has a protective effect against induced hepatoxicity in Rats.
Methods: The experimental groups were divided into Normal group (untreated Group), Control group , Sample 1 (group treated with 0.1 ml Plantaginis Semen herbal acupuncture in both sides of after treating) and Sample 2 (group treated with feeding of 1 cc Plantaginis Semen extraction after treating). Rats were administered orally for 4 days. In experiments for PS effect, rats of Sample 1 group received 0.lml herbal acupuncture of PS extraction in both sides of corresponding of human body for 3 days after treated . Rats of Sample 2 group feeded PS extraction (1cc) for 3 days after treated . Variation of weight and biochemical assays (AST, ALT, LDH, ALP, total cholesterol, triglyceride, total protein, albumin) were performed.
Results: In Control group, increased serum AST, ALT, LDH, ALP, total protein, albumin and decreased weight, total cholesterol, triglyceride. Sample 1 and Sample 2 significantly decreased serum AST, ALT, LDH, ALP, total protein, albumin as compared with Control group.
Conclusion: These results indicate that PS could be used in prevention and treatment of hepatoxicity. However, precise mechanisms of PS protection remain to be determined.
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KEYWORD
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Plantaginis Semen, herbal acupuncture, hepatoxicity
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