KMID : 1129720060230030111
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Korean Journal of Acupuncture 2006 Volume.23 No. 3 p.111 ~ p.122
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Effect of scutellariae radix pharmacopuncture on the type 1 hypersensitivity
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Kim Yu-Seung
Song Chun-Ho
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Abstract
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Objectives : We studied the effects of Scutellariae Radix pharmacopuncture solution (SRHAS) on the type 1 hypersensitivity.
Methods : In vivo, we measured compound 48/80-induced active systemic anaphylactic shock using ICR mice and anti-DNP IgE-induced passive cutaneous anaphylaxis (PCA) using Sprague Dawley rats. In vitro, we showed effects on cytotoxicity and release from RBL-2H3 cells.
Results : In vivo, SRHAS pretreatments (100% or 50%) at BL13 inhibited active systemic anaphylactic shock induced by compound 48/80. PCA was only inhibited by pretreatments of SRHAS at optional points. In vitro, SRHAS treatments did not affect cell viability while -hexosaminidase release was significantly inhibited.
Conclusions : These results suggest that SRHAS may be beneficial in the inhibition of type I hypersensitive inflammatory response.
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KEYWORD
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Scutellariae Radix, pharmacoacupuncture, type I hypersensitivity
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