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KMID : 1129720060230040169
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Korean Journal of Acupuncture
2006 Volume.23 No. 4 p.169 ~ p.176
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Acupuncture at Liver Meridian Protects the Dopaminergic Neuronal Damage in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s Disease Mouse Model
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Kim Seung-Tae
Park Hi-Joon
Chae Youn-Byoung
Kim Youn-Jung
Kang Min-Jung
Jung Mi-Young
Chung Joo-Ho
Hahm Dae-Hyun
Lee Sang-Jae
Lee Hye-Jung
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Abstract
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Objectives : This study was designed to compare the effects of tonification and sedation methods of Liver Meridian in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease mice model.
Methods : We injected MPTP (30 mg/kg, i.p.) or saline for 5 consecutive days. Acupuncture treatments were given to the mice with MPTP at LR8 and LR4 to tonify Liver Meridian (Liver+) or LR4 and LR2 to sedate it (Liver-) for 12 day. At the 12th day after first injection, mice were perfused, and then tyrosine hydroxylase (TH)-immunohistochemistry was performed in substantia nigra (SN) of their brains. After counting the number of TH-positive neurons, we compared their numbers among experimental groups.
Results : The number of TH-positive neurons of Liver+ group was significantly increased compared to that of MPTP group in the SN. That of Liver-group was also increased more than MPTP group, but not significantly.
Conclusions : Tonifying Liver Meridian might be effective therapeutic tools for the neuroprotection in subchronic MPTP-induced mice model.
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KEYWORD
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acupuncture, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), tonification, sedation, Liver Meridian
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