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KMID : 1129720070240010161
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Korean Journal of Acupuncture
2007 Volume.24 No. 1 p.161 ~ p.170
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Effects of herbal-aupuncture solution from vitis labrusca root on LPO, RNS and cytochrome P450
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Lim Seong-Chul
Kim Hyuck
Lee Hyo-Seung
Park Won-Hwan
Moon Jin-Young
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Abstract
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Objectives : In this study, we determinated protective effects of Vitis labrusca Root herbal-acupuncture solution (VLHA) against atherosclerosis and cardiovascular disease induced by oxidative damage and cytochrome P450 (CYP) induction.
Methods : Antioxidant capacity of VLHA were evaluated by the acid emulsion system and FeCl2-ascorbic acid stimulted lipid peroxidation in rat liver homogenate, respectively. Scavenging effects of VLHA on ONOO- and NO were measured by DHR 123, DAF-2 assay. Furthermore, we measured inhibitory activity of VLHA on CYP 2E1 in rat liver microsome using by Aniline assay.
Results : VLHA exhibited potent inhibition rate(74%) on FeCl2-ascorbic acid induced lipid peroxidation, and revealed a strong scavenging effects on ONOO- and NO. In addition, VLHA showed inhibitory effect on CYP 2E1.
Conclusions : The present study concludes that our results suggest that VLHA could be used as a good source in the prevention of atherosclerosis and alcoholic liver injury.
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KEYWORD
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cytochrome P450, lipid peroxidation, NO, ONOO-, Vitis labrusca Root
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