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KMID : 1129720070240030179
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Korean Journal of Acupuncture
2007 Volume.24 No. 3 p.179 ~ p.204
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A Study on the Effect of Angelicae Radix Pharmacopuncture at Joksamni(ST36) on Collagen-induced Arthritis in DBA/1J Mice
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Kim Tae-Han
Lee Byung-Ryul
Lee Hyun
Yim Yun-Kyoung
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Abstract
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Objectives & Methods : The purpose of this study is to observe the effects of Angelicae Radix Pharmacopuncture(AR-P) at Joksamni(ST36) on collagen II induced arthritis in DBA/1J mice. The authors evaluated arthritis index, arthritis incidence and joint edema, and measured body weight, spleen size and stenosis rate, serum cytokine level, serum antibody level, immune cell populations In spleen, lymph node, and knee joint, and performed histological analysis of CIA mouse joint.
Results : In the AR-P group, arthritis index, arthritis incidence and joint edema were decreased, and the enlargement, malformation and stenosis of spleen and the malformation of joint appeared milder than the control group. In AR-P group, the levels of , IL-6, , in serum were significantly decreased. And the level of anti-collagen II in serum was maintained lower in AR-P group than in the control group. In AR-P group, the level of and IL-10, and ratio were significantly decreased, and the ratios of cells to cells, cells to cells in spleen were similarly maintained as those of the normal group. In the AR-P group, the populations of cells in spleen and lymph nodes, cells in lymph nodes, $CD3^+/CD69^+$ cells and cells in knee joint were decreased. In the histological analysis, the cartilage destruction, synovial cell proliferation and the collagen fiber destruction were decreased in the AR-P group
Conclusions : The results suggest that AR-P at right ST36 has a therapeutic effect on collagen-induced arthritis in mice.
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KEYWORD
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Angelicae Radix, Pharmacopuncture, ST36, Rheumatoid Arthritis(RA), Collagen-induced Arthritis(CIA)
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