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KMID : 1129720070240040111
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Korean Journal of Acupuncture
2007 Volume.24 No. 4 p.111 ~ p.129
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Effects of Herbal-acupuncture with Coicis Semen Solution at Joksamni (ST36) on Collagen-induced Arthritis in DBA/1J Mouse
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Lee Seong-No
Lee Hyun
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Abstract
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Objectives & Methods: The purpose of this study is to observe the effects of Coicis Semen Herbal-acupuncture solution (CS-HAS) at the Joksamni (ST36) on the collagen-induced arthritis in the DBA/1J mouse. The author performed several experiments to analyze the effects of CS-HAS on arthritis; change of the weight; the spleen size and adhesion rate; serum cytokine levels; serum antibody levels; changes of immunocyte counts; the histological changes of joint.
Results: In the Coicis Semen Herbal-acupuncture (CS-HA), arthritis index, the incidence of arthritis, and the degree of joint edema were decreased. In CS-HA, there was no weight loss. The size of the spleen, adhesion rate, and the edema and transformation of joint were lowered. In CS-HA, the levels of IL-1b, IL-6, TNF-a, IFN-r, IgG, IgM, and anti-collagen II in serum and the levels of IFN-r, IL-4, IL-10 in spleen were significantly decreased. In CS-HA, the expression ratios of CD45? to CD3e? and CD8? to CD4? were decreased. Also, the overall CD4?/CD8? cell ratio was lowered in spleen. Ratios of the CD4?/CD25?, CD45?/CD69? cells were decreased in lymph nodes. In addition, ratios of the CD3?/D69?, CD116/Gr-1? cells were also decreased in synovium. In the histological study, the cartilage destruction and synovial cell proliferation, and collagen fiber destruction were decreased with CS-HA treated group.
Conclusions: From the results mentioned above, it is suggested that CS-HA at the ST36 has several significant effects on the collagen-induced arthritis.
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KEYWORD
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Coicis Semen, Pharmacopuncture, Rheumatoid Arthritis (RA), ST36
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