KMID : 1129720080250010213
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Korean Journal of Acupuncture 2008 Volume.25 No. 1 p.213 ~ p.227
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Effect of Semen Perillae herbal acupuncture on the type 1 hypersensitivity
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Song Se-Hoon
Song Chun-Ho
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Abstract
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Objectives: We studied on anti-allergic effects of Semen Perillae Herbal Acupuncture(SPHA) and Semen Perillae Herbal Acupuncture Solution(SP).
Methods: In vivo, Animals were herbal-acupunctured SPHA at both ST36 three times for 5 days. Then, we investigated compound 48/80-induced active systemic anaphylaxis (ASA) using ICR mice and anti-DNP IgE-induced passive cutaneous anaphylaxis (PCA) using Sprague Dawley rat. In vitro, we measured cell viability, b-hexosaminidase release, IL-4 and TNF-a from RBL-2H3 cells after treatment of SP of various concentrations.
Results: In vivo, SPHA pretreatments at both ST36 inhibited compound 48/80-induced ASA. PCA was inhibited by SPHA pretreatments at both ST36 and optional points. In vitro, SP treatments were not affect on cell viability and inhibited b-hexosaminidase release, IL-4 and TNF-a.
Conclusions: These results suggest that SPHA and SP may be beneficial in the inhibition of allergic inflammatory response.
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KEYWORD
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SemenPerillae, herbalacupuncture, allergy, RBL-2H3cell
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