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KMID : 1129720080250030081
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Korean Journal of Acupuncture
2008 Volume.25 No. 3 p.81 ~ p.96
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A Study of Antinociception of Electroacupuncture to SI6 on the Acute Ankle Sprained Rats
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Yang Beom-Sik
Kim Jae-Hyo
Ahn Seong-Hun
Kim Kyung-Sik
Sohn In-Chul
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Abstract
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Objectives: The purpose of the present study is to determine the effective analgesic parameters of manual
acupuncture (MA) and/or electroacupuncture (EA), thus how MA & EA of specific acupoint works after acute ankle sprain in rats. Thus, one series of experiments was designed to analyze the analgesic effects of acupuncture in either the normal or sprained rat, by comparing the behavioral features before and after MA or EA at several acupoints.
Methods: Ankle sprain was induced manually by hyper-extension of ligaments of the right ankle in rat. Either MA or EA was applied to the LI4, TE17, 足三里 and SI-6 acupoints at an intensity of 2 mA (1 ms pulse duration) with a frequency of 10 Hz for 30 minutes.
Results: Behaviorally, manual acupuncture or electroacupuncture produced potent analgesic effects on acute
ankle sprained animals as measured by weight bearing capacity of the affected limb. Furthermore, antinociceptive effect of EA was suppressed by alpha adrenoceptor antagonist phentolamine (5 mg/kg, i.p.) but not by opioid antagonist naltrexone (10 mg/kg, i.p.).
Conclusions: It is suggested that acupuncture-induced antinociception may involve the descending inhibition
of α2-adrenoceptor.
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KEYWORD
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SI6, Acute ankle sprain, electroacupuncture
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