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KMID : 1129720090260010061
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Korean Journal of Acupuncture
2009 Volume.26 No. 1 p.61 ~ p.77
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Anti-inflammatory Effect of Dianthi Semen Herbal-acupuncture at KI10 on nephritis in rats
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Kim Kyung-Min
Lee Hyun
Yim Yun-Kyoung
Lee Yong-Heum
Kang Hee-Jung
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Abstract
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Objective: This study aimed to evaluate the effects of Dianthi Semen Herba herbal-acupuncture (DS-HA) at KI10 (Umgok) on nephritis induced by LPS in rat.
Methods: Rats were injected with LPS and treated with DS-HA at KI10 3 times for a week(DS-HA), N.P. group was treated 26 gauge needle at KI10, saline group was treated with normal saline at KI10. To estimate the effects of DS-HA at KI10 on nephritis in rats, WBC, neutrophils in blood, BUN, creatinine TNF-α, CINC-1 in serum, urinal volume and creatinean and total protein in urine, reanl TNF-α, renal MPO were measured and histological analysis of renal tissue was performed.
Results: DS-HA at KI10 significantly decreased WBC and neutrophil in blood and BUN and creatinin in serum, MPO in kidney, and significantly increased urinary volume in LPS-stimulated rats. DS-HA at KI10 reduced accumulation of neutrophil in renal tissue of LPS-stimulated rats.
Conslusions: Taken together, DS-HA at KI10 has a protective or therapeutic effect for nephritis in LPS-stimulated rat. Therefore, it is suggested that DS-HA at KI10 may be an useful therapeutics in clinical field after further researches.
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KEYWORD
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Nephritis, Herbal-acupuncture, KI10, Dianthi Semen
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