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KMID : 1129720090260020109
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Korean Journal of Acupuncture
2009 Volume.26 No. 2 p.109 ~ p.126
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Effects of gamgook(Chrysanthemum indicum L.) herbal-acupuncture on lipid lowering effect, anti-oxidative capacity and anti-inflammatory effect in rat fed high oxidized fat
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Im Yun-Taek
Lee Hyang-Sook
Lee Joon-Moo
Lee Eun
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Abstract
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Objectives: To investigate the effects of Chrysanthemum indicum L. pharmacopuncture on lipids, antioxidant capacity and anti-inflammation in rats fed high-fat diet.
Methods: Hyperlipidemic rats induced by high-fat diet were divided into 5 groups: no treatment control (normal, n=8), high-fat diet only control (control, n=8), high-fat diet and Chrysanthemum indicum L. pharmacopuncture at CV4 group (TI, n=8), high-fat diet and Chrysanthemum indicum L. pharmacopuncture at CV17 group (TII, n=8), and high-fat diet and
Chrysanthemum indicum L. pharmacopuncture at EX-HN3 group (TIII, n=8). They were given pharmacopuncture accordingly every other day for two weeks followed by analyses of lowering lipids effects, oxidative capacity and anti-inflammatory effects.
Results: Compared with the control, pharmacopuncture groups showed significantly decreased plasma total cholesterol (TC), liver thiobarbituric acid reactive substance (TBARS), catalase, glutathione peroxidase, neutrophils, monocytes, plasma and liver IL-1β, and plasma and liver IL-6. In other parameters including plasma and liver triglyceride, liver TC, LDL-cholesterol, HDL-cholesterol, liver TBARS, supraoxide dismutase, total protein, albumin, blood cell
analysis, plasma and liver TNF-α, and IL-10, there was no significant difference between control and pharmacopuncture groups. No clear acupoint-specificity was observed.
Conclusions: Chrysanthemum indicum L. pharmacopuncture may improve control of hyperlipidemia.
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KEYWORD
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Chrysanthemum indicum L., pharmacopuncture, oxidized fat, lipid lowering, anti-inflammatory, anti-oxidative
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