KMID : 1129720090260020127
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Korean Journal of Acupuncture 2009 Volume.26 No. 2 p.127 ~ p.143
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Anti-inflammatory Effect of Plantaginis Semen Herbal-acupuncture at KI10 on LPS-induced nephritis in rats
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Park Byong-Mun
Hur Boo Yim Yun-Kyoung
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Abstract
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Objective : This study aimed to evaluate the effects of Plantaginis Semen herbal-acupuncture (PS-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide (LPS) in rat.
Methods : The authors performed several experimental items including measurements of urinary volume, WBC in blood, BUN, creatine, TNF-¥á, CINC-1 in serum, creatinine, total protein in urine, TNF-¥á, MPO in kidney and histological analysis of renal tissue.
Results : PS-HA at KI10 significantly reduced WBC in blood, BUN, TNF-¥á in serum of LPS-stimulated rats. PS-HA at KI10 significantly increased urinary volume in LPS-stimulated rats. And PS-HA at KI10 significantly reduced MPO in kidney of LPS-stimulated rats.
Conclusion : Taken together, PS-HA at KI10 has a therapeutic effect on nephritis in LPS-stimulated rat. Therefore, it is suggested that PS-HA at KI10 may be an useful therapeutics for nephritis in clinical field.
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KEYWORD
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Nephritis, Herbal-acupuncture, KI10, Plantaginis Semen
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