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KMID : 1129720110280030073
Korean Journal of Acupuncture
2011 Volume.28 No. 3 p.73 ~ p.83
Effect of Glycyrrhizae Radix Pharmacopuncture on PCA and Secretion of -Hexosaminidase and Cytokines in RBL-2H3 Cells
Lee Hang-Do

Song Cunn-Ho
Abstract
Objectives: The purpose of this study is to investigate anti-allergic effects of Glycyrrhizae Radix(GR) pharmacopuncture and GR extract.

Methods: In vivo, animals were gotten GR pharmacopunctures at both sides of ST36s three times for 5 days. Then, we investigated anti-DNP IgE-induced passive cutaneous anaphylaxis of Sprague Dawley rats. In vitro, we measured cell viability, -hexosaminidase release, and the secretion of interleukin-4(IL-4) and tumor necrosis factor-alpha(TNF-) in RBL-2H3 cells after treatment of various concentrations of GR extract. R

Results: In vivo, we observed inhibition of passive cutaneous anaphylaxis after GR pharmacopuncture treatments at both sides of ST36s and optional points. In vitro, GR extract treatments did not affect cell viability, but inhibited -hexosaminidase release and the secretion of IL-4 and TNF-.

Conclusions: These results suggest that GR pharmacopuncture and GR extract should be beneficial in the inhibition of allergic inflammatory response.
KEYWORD
Glycyrrhizae Radix, Pharmacopuncture, Allergy, RBL-2H3 cells
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