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KMID : 1129720120290030396
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Korean Journal of Acupuncture
2012 Volume.29 No. 3 p.396 ~ p.405
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Acupuncture Treatment at HT8 Supresses Seizure and Inflammation in Hippocampi on an Epilepsy Mice Model
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Doo Ah-Reum
Kim Seung-Nam
Yin Chang-Shik
Kim Youn-Jung
Lee Hye-Jung
Kim Seung-Tae
Park Hi-Joon
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Abstract
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Objectives: To confirm whether acupuncture can suppress the degree of seizure and the activation of astrocytes in hippocampi using kainic acid(KA)-induced epilepsy mouse model.
Methods: 8 weeks C57BL/6 mice(20~25 g) were given acupuncture once a day at acupoint HT8(Shaofu) bilaterally during 2 days before KA injection. After an intraperitoneal injection of 30 mg/kg KA, acupuncture treatment was subsequently administered once more(total 3 times), and the degree of seizure was observed for 120 min. The neuronal cell death, pERK expression, and astrocyte activation confirmed 1 hour and 24 hours after KA injection.
Results: Acupuncture treatment at HT8 suppressed KA-induced epileptic seizure. One hour after KA injection, the pERK expression was increased, which was reduced by the acupuncture treatment. Twenty four hours after injection, the treatment decreased the KA-induced neuronal cell death, the interleukin-1β expression and the astrocyte activation in the CA3 region of the mouse hippocampus.
Conclusions: Acupuncture treatment at HT8 decreases the KA-induced epileptic seizure, the neural cell inflammation and death.
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KEYWORD
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acupuncture, HT8, epilepsy, seizures, inflammation
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