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KMID : 1129720130300010073
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Korean Journal of Acupuncture
2013 Volume.30 No. 1 p.73 ~ p.80
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Acupuncture Stimulation at LI11 Suppresses Seizure and Apoptosis in Hippocampi on an Epilepsy Mouse Model
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이종분:Lee Jong-Boon
황경민:Hwang Kyoung-Min/유태원:Yoo Tae-Won/배창환:Bae Chang-Hwan/권선오:Kwon Sun-Oh/김승태:Kim Seung-Tae
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Abstract
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Objectives : LI11 has been known to suppress epileptic seizure. Using an mouse epilepsy model, we investigated whether acupuncture stimulation at LI11 can suppress kainic acid(KA)-induced epileptic seizure and apoptosis in the mouse hippocampus.
Methods : Eight-week-old male C57/BL6 mice(20∼25 g) were given acupuncture at LI11 or ST36 once a day for 3 days. After the last acupuncture stimulations, KA(30 mg/kg) was injected intraperitoneally and the degree of seizure was observed for 90 minutes. Twenty-four hours after KA administration, mice were sacrificed and the neural cell death, astrocyte activation and caspase-3 expression in their hippocampi were investigated.
Results : Acupuncture stimulation at LI11 suppressed KA-induced epileptic seizure, neuronal cell death, astrocyte activation and caspase-3 expression.
Conclusions : Acupuncture stimulation at LI11 decreases the KA-induced epileptic seizure and protects hippocampal cell death via regulating astrocyte activation and caspase-3 expression.
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KEYWORD
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acupuncture, LI11, epilepsy, kainic acid, astrocyte, caspase-3
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