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KMID : 1129720130300040220
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Korean Journal of Acupuncture
2013 Volume.30 No. 4 p.220 ~ p.229
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The Mechanism for Analgesic Effects of Electroacupuncture on Surgical Ankle Sprain Model Classified as Grade 3 in Rats
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양승범:Yang Seung-Bum
최석준:Choi Suck-Jun/이성호:Lee Sung-Ho/김민수:Kim Min-Su/손인철:Sohn In-Chul/김재효:Kim Jae-Hyo
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Abstract
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Objectives : Electroacupuncture(EA) has been used effectively in producing analgesia on ankle sprain pain of humans and animals. Currently to examine the underlying mechanisms of the EA-induced analgesia, the effects of EA on weight-bearing forces(WBR) were examined at ankle sprain classified as grade 3 in rats.
Methods : The severe ankle sprain classified as grade 3 was induced surgically by ankle ligament injury in the Sprague-Dawley rats. WBR of the affected foot were examined to evaluate effects and mechanism of EA(2 Hz, 1 ms pulse width, 2 mA intensity, for 15 min) which was applied to either SI6, GB34, or GB39 acupoints. The rats were pretreated with naltrexone(10 mg/kg, i.p.) as an opioid receptor antagonist or phentolamine(5 mg/kg, i.p) as an α -adrenoceptor antagonist at 30 min before EA.
Results : The daily repeat EA at either SI6, GB34, or GB39 showed significant analgesic effects on the severe ankle sprain. Particularly, daily EA at GB34 showed more potent analgesic effect than the others. In addition, the naltrexone pretreatment completely blocked the analgesic effect of EA at GB34, indicating the involvement of the endogenous opioid system in mediating the effect of EA at GB34. However, the phentolamine pretreament blocked analgesic effects of EA at either SI6 or GB39, indicating the involvement of α-adrenoceptors in mediating the effect of EA at either SI6 or GB39.
Conclusions : These data suggest that EA-induced analgesia on ankle sprain pain is mediated through either endogenous opioids or α-adrenoceptors dependant on acupoint specific pattern.
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KEYWORD
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ankle sprain, electroacupuncture, analgesia, point specificity, endogenous opioids, α-adrenoceptors
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