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KMID : 1129720130300040243
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Korean Journal of Acupuncture
2013 Volume.30 No. 4 p.243 ~ p.251
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Anti-Inflammatory Effect of Bower Actinidia in LPS-Stimulated RAW264.7 Cells
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김영준:Kim Young-Jun
송춘호:Song Choon-Ho
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Abstract
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Objectives: Bower Actinidia has been widely used for treatment of inflammatory diseases, such as jaundice, cystolithiasis. However, the mechanism of its anti-inflammatory activity has not been clarified. In this study, we investigated the inhibitory effect of Bower Actinidia pharmacopuncture extract(BA) on LPS-induced inflammation.
Methods: The effect of BA was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells.
Results: We found that BA suppressed not only the mRNA expression of pre-inflammatory cytokines, cyclooxygenase-2(COX-2) and inducible nitric oxide synthase(iNOS), but also the phosphorylation of ERK, JNK and p38.
Conclusions: These results suggest that BA exerts an anti-inflammatory effect through the regulation of the mitogen-activated protein kinase(MAPK) pathway, thereby decreasing production of pre-inflammatory cytokines.
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KEYWORD
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Bower Actinidia, pharmacopuncture, inflammation, MAPK, RAW264.7 cells
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