|
KMID : 1129720130300040298
|
|
Korean Journal of Acupuncture
2013 Volume.30 No. 4 p.298 ~ p.304
|
|
|
Mutual Inhibitory Effects of Electroacupuncture Applied to Combination of ST36 and PC7 in the Rat Model of Arthritis
|
|
김여정:Kim Yeo-Jung
정연정:Jung Yun-Jung/이창형:Lee Chang-Hyung/구성태:Koo Sung-Tae
|
|
|
Abstract
|
|
|
Objectives : We examined mutual inhibitory effects of combined acupoints in arthritic pain induce by carrageenan(CA). Electroacupuncture(EA) is considered a potentially useful treatment for arthritis. Although the analgesic effect of acupuncture is well documented, little is understood about its biological basis. There are many previous studies of positive effect of combined acupoint, this study was conducted to see the mutual inhibitory effects produced by combined acupoint(ST36 and PC7) on arthritic rats.
Methods : For the induction of inflammatory pain rat model, CA was injected into the knee joint cavity. There are four groups; EA was applied to bilateral PC7 acupoints(PC7 group), ST36 acupoints(ST36 group), and both PC7 and ST36 acupoints(ST36+PC7 group) except for the control group. The pain level were assessed to determine the change in weight bearing force. We also examined the COX-2 expression in dorsal horn using immunohistochemistry and western blot analysis.
Results : The ST36+PC7 group data showed the significant reduction of weight bearing force and the induction of COX-2 protein expression compared with the ST36 group.
Conclusions : Simultaneous EA applied to the ST36 and PC7 acupoints reduced the analgesic effect of the ST36 group on knee inflammatory pain.
|
|
|
KEYWORD
|
|
|
carrageenan induced arthritis, electroacupuncture, weight bearing, COX-2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|