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KMID : 1129720180350010027
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Korean Journal of Acupuncture
2018 Volume.35 No. 1 p.27 ~ p.35
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Analgesia of Electroacupuncture and Radio-Frequency Warm Needling in Acupoint Combination on Ankle Sprain in Rats
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Yang Seung-Bum
Kim Min-Su
Kim Jae-Hyo
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Abstract
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Objectives: The purpose of this study was to investigate the analgesic effect of electroacupuncture(EA) and radio-frequency warm needling(RFWN) stimulation in acupoint combination on ankle sprained pain in rats.
Methods: The lateral ligaments of the Sprague-Dawley rats ankle were injured surgically resulting in sprain, of which was divided into EA, RFWN treatment groups and control group without treatment. The level of pain was measured through foot weight bearing force ratio followed by calculating pain relief. To stimulate proximal or distal area in ankle sprain, combination of proximal acupoints(GB34-GB39) and distal acupoints(GB39-GB42) from sprain area were applied, respectively, to either EA or RFWN stimulation. In addition, naltrexone or phentolamine was injected intraperitoneally before the stimulation to observe the pathway of analgesic effects.
Results: In the proximal combination of GB34-GB39, EA and RFWN significantly increased pain relief compared to the control group (p<0.05). However, in distal combination with GB39-GB42, both EA and RFWN stimulation did not relieve pain due to ankle sprains. In the combination of GB34-GB39, the analgesia of EA was inhibited by blockade of the α-adrenoceptor receptor. The analgesia of RFWN was inhibited by blockade of the α-adrenoceptor receptor as well as μ-opioid receptor.
Conclusions: We observed that the proximal combination was effective in relieving pain when the treatment by acupoint combination was applied to the ankle sprain pain. Also, it was confirmed that this analgesia was also related to the pathways of μ-opioid receptors and/or α-adrenoceptors.
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KEYWORD
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ankle sprain, electroacupuncture, radio-frequency warm needling, acupoint combination
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