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KMID : 1129720180350030139
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Korean Journal of Acupuncture
2018 Volume.35 No. 3 p.139 ~ p.148
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Thirteen Weeks Repeated-dose Toxicity Study on Aconitum ciliare Decaisne Pharmacopuncture Solution in Mice
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Lim Seong-Chul
Kim Jae-Soo
Lee Bong-Hyo
Lee Hyun-Jong
Lee Hyun
Lee Yun-Kyu
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Abstract
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Objectives : This study was performed to examine the toxicity on the long term procedure of Aconitum ciliare Decaisne pharmacopuncture(ADP) solution.
Methods : To evaluate the long term toxicity of 3 different repeated doses, 60, 150, and 300 mg/kg/day for 13 weeks were injected into BALB/c mice, respectively. The ADP solution was injected into near ST36 of the right leg and normal saline of the same volume was used for the vehicle control group. To evaluate the toxicity of 60, 150, and 300 mg/kg of repeated doses for 13 weeks, toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were conducted.
Results : No significant changes in toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were observed in different doses of ADP solution treated groups compared to vehicle control group. Conclusions : As a result, repeated dose at a concentration of 300 mg/kg or less is considered to be not harmful for clinical treatment.
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KEYWORD
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Aconitum ciliare Decaisne, pharmacopuncture, toxicity, repeated dose
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