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KMID : 1129720190360010063
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Korean Journal of Acupuncture
2019 Volume.36 No. 1 p.63 ~ p.73
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Effects of Alismatis Rhizoma Pharmacopuncture at BL23 on Cisplatin-Induced Acute Renal Failure in Rats
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Kim Myung-Sik
Kim Jae-Hong
Youn Dae-Hwan
Jung Hyun-Woo
Cho Myoung-Rae
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Abstract
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Objectives : This study was designed to investigate the effects of Alismatis Rhizoma (AR) pharmacopuncture at BL23 on acute renal failure induced by cisplatin.
Methods : The Sprague-Dawley rats were divided into Normal group (no injection of cisplatin and no treatment), Control group (cisplatin injection without treatment), Acu group (needling at BL23 after cisplatin injection), AR-PA1 group (treated with 0.3571 mg/kg/20 μl of AR pharmacopuncture at BL23 after cisplatin injection), and AR-PA2 group (treated with 1.7855 mg/kg/20 μl of AR pharmacopuncture at BL23 after cisplatin injection). Each treatment was given once daily for 8 days. Changes in body weight, kidney weight, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GPx), serum blood urea nitrogen (serum BUN), and serum creatinine were observed.
Results : Body weight was significantly increased in AR-PA1 on 4th and 6th days and AR-PA2 on 2nd day. TNF-α was significantly decreased in Acu, AR-PA1 and AR-PA2 groups. Cu-Zn SOD was significantly increased in AR-PA2 group. GPx was significantly increased in AR-PA1 and AR-PA2 groups. But kidney weight, IL-6, serum BUN and serum creatinine were not significantly changed in any groups compared to control group.
Conclusions : In acute renal failure induced by cisplatin, AR pharmacopuncture has a mitigating effect on the inflammatory reaction related to the increase of TNF-α in the kidney tissue and a protective effect on the oxidative stress of the kidney tissue. However it is unlikely to restore the glomerular function or inhibit the renal swelling.
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KEYWORD
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Alismatis Rhizoma, Pharmacopuncture, BL23, Cisplatin, Acute renal failure
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