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KMID : 1129720190360010074
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Korean Journal of Acupuncture
2019 Volume.36 No. 1 p.74 ~ p.80
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Toxicity Evaluation of TA, a Pharmacopuncture Medicine, in an in Vivo Micronucleus Test
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Hwang Ji-Hye
Jung Hyo-Won
Jung Chul
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Abstract
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Objectives : TA, a polyherbal extract, typically is used for pharmacopuncture therapy on patients with traffic accident-related injuries and musculoskeletal diseases. This study was performed to evaluate the safety of the TA extract, using a micronucleus test.
Methods : The dose range and sampling time were first established. An in vivo micronucleus test was then performed to determine the induction of micronuclei in mouse bone marrow cells after a single intramuscular administration of TA to 7-week-old ICR mice (0.2 ml/animal, at 24 hours post-dosing).
Results : The incidence of micro-nucleated polychromatic erythrocytes (PCEs) in PCEs in the TA group was similar to that in the negative-control group, while that in the positive-control group was significantly greater. The positive- and negative-control groups did not differ in the ratio of PCEs to total erythrocytes.
Conclusions : Our toxicity study indicates that the TA extract does not induce micronucleus formation in mouse bone marrow cells.
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KEYWORD
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micronucleus, pharmacopuncture, safety, TA extract, toxicity test
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