KMID : 1129720190360040200
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Korean Journal of Acupuncture 2019 Volume.36 No. 4 p.200 ~ p.209
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The Effects of Acupuncture at LR3 Acupoint on Mitochondrial Complex IV Oxidase activity in Liver
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Choi Dong-Hee
Lee Yu-Mi Kim Mi-Rae Park Jeong-Hye Kim Hye-Ran Na Chang-Su Youn Dae-Hwan
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Abstract
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Objectives : The liver is rich in mitochondria and it plays a key role in whole-body energy homeostasis. Mitochondria is double membrane-bound organelle that supplies energy for intracellular metabolism including Krebs cycle and beta-oxidation. Acupuncture is known to stimulate and regulate the flow of energy. To explore the effect of acupuncture on the mitochondrial respiratory chain activity in the rats¡¯ livers, the activity of mitochondrial respiratory chain complexes I to IV was observed.
Methods : The rats were divided into 4 groups; Normal 1 (no acupuncture treatment and anesthesia for 5 min), Normal 2 (no acupuncture treatment and anesthesia for 10 min), MA1 (acupuncture treatment at bilateral LR3 under anesthesia for 5 min), and MA2 (acupuncture treatment at bilateral LR3 under anesthesia for 10 min). All rats were sacrificed and the livers were examined for respiratory chain change.
Results : There was no difference in ubiquinon oxidoreductase, succinate dehydrogenase, and ubiquinol cytochrome C oxidoreductase after acupuncture at LR3. Acupuncture at LR3 for 10 min increased the activity of cytochrome C oxidase compared with no acupuncture groups.
Conclusions : Acupuncture at LR3 mediated mitochondrial respiratory chain activity via the cytochrome C oxidase signaling pathway in the livers of rats.
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KEYWORD
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LR3 acupoint, ubiquinon oxidoreductase, succinate dehydrogenase, ubiquinol cytochrome C oxidoreductase, cytochrome C oxidase
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