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KMID : 1129720200370010024
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Korean Journal of Acupuncture
2020 Volume.37 No. 1 p.24 ~ p.30
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Inhibitory Effect of Polyporus umbellatus Extract on Melanogenesis
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Kang Lea Min-Ju
Park Seol-A
Mun Yeun-Ja
Woo Won-Hong
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Abstract
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Objectives : The purpose of this study was to investigate melanogenesis inhibition of ethanol extract of Polyporus (EP) by using B16F10 melanoma cells.
Methods : We measured antioxidant effect of EP by using 1,1-Diphenyl-1-picrylhydrazyl (DPPH) assay and we confirmed melanin contents and tyrosinase activity of EP in cells. Additionally, the expression of tyrosinase-related protein-1 (TRP-1) and TRP-2 was observed by Western blot.
Results : EP showed significantly high radical scavenging activity and inhibition of melanogenesis in dose-dependent manner by decreasing cellular tyrosinase activity and melanin content with or without α-melanin stimulating hormone. TRP-1 and TRP-2 expressions were also suppressed by EP in B16F10 cells.
Conclusions : These results suggest that EP inhibits the melanogenesis and it could be a new organic ingredient for hyper-pigmentation.
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KEYWORD
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Polyporus, tyrosinase activity, melanin, tyrosinase-related protein-1, tyrosinase-related protein-2, α-melanin stimulating hormone
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