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KMID : 1144420190340040284
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Acute and Critical Care
2019 Volume.34 No. 4 p.284 ~ p.288
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A successful application of adult polymyxin B-immobilized fiber column hemoperfusion to a neonate with septic shock
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Kim Young-A
Kim Hyung-Tae
Kim Yu-Mi
Park Su-Eun
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Abstract
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Direct hemoperfusion therapy with a polymyxin B-immobilized fiber column (PMX-HP) has been introduced as a therapeutic option for gram negative bacterial septic shock in adults. However, its use in neonates and children has not yet been established. We successfully performed hemoperfusion therapy using an adult polymyxin B-immobilized fiber column in a neonate with carbapenem resistant Acinetobacter baumannii septic shock. The application was technically feasible because the neonate was on extracorporeal membrane oxygenation (ECMO). Although it did not rescue the patient, there was significant short-lasting improvement in pulmonary oxygenation and hemodynamics, leading to wean the patient from ECMO. PMX-HP could be used as an adjunctive treatment for selected neonatal and pediatric patients with gram negative bacterial septic shock.
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KEYWORD
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extracorporeal membrane oxygenation, hemoperfusion, neonate, polymyxin B
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