KMID : 1145320140030020001
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Journal of Korea Immuno-yakchim Society 2014 Volume.3 No. 2 p.1 ~ p.8
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Anti-inflammatory Activity of B Yakchim Fluid on the LPS-stimulated RAW 264.7 Macrophages
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Lee Kyung-Jin
Jung Chul Kim Hak-Ju
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Abstract
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Objectives : The purpose of this study was to investigate the anti-inflammatory activities of B Yackchim fluid.
Methods : The total sugar, total reducing sugar, and protein contents in B Yackchim fluid were analyzed. To investigate the anti-inflammatory effects of B Yackchim fluid, nitric oxide (NO), interleukin-2 (IL-2), interleukin-6 (IL-6), and tumor necrosis factor-¥á (TNF-¥á) in the LPS-stimulated RAW 264.7 macrophage were measured.
Results : B Yackchim fluid consists of 0.12 mg/ml of total sugar, 0.08 mg/ml of total reducing sugar. However, total protein was not detected. B Yackchim fluid showed anti-inflammatory effects by reducing the production of NO, IL-2, IL-6, and TNF-¥á. However, B Yackchim fluid showed cell cytotoxicity.
Conclusions : B Yackchim fluid might have anti-inflammatory effects. However, more studies including efficacy and safety should be needed to use anti-inflammatory agent in Korean medicine.
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KEYWORD
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B Yackchim, Anti-inflammatory effect, Nitric oxide, Interleukin-2, Interleukin-6, Tumor necrosis factor-¥á
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