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KMID : 1145320150040010001
Journal of Korea Immuno-yakchim Society
2015 Volume.4 No. 1 p.1 ~ p.7
Single Intramuscular Dose Toxicity Study of CS¥±-YAKCHIM in Sprague-Dawley Rats
Kim Su-Kyeong

Jung Chul
Abstract
Objectives : CS¥±-YAKCHIM was developed to reduce pain in traditional Korean medicine. However, the safety of CS¥±-YAKCHIM has not been studies. In the present study, single intramuscular dose toxicity study of CS¥±-YAKCHIM was performed in 6-week old male and female Sprague-Dawley (SD) rats.

Methods : Test groups consisted of one dosing group at a dose of 1.0 mL/animal and one control group (saline), and 5 males and 5 females were assigned to each group. All animals were monitored for clinical signs and body weight changes during the 14-day observation period after administration. They were subjected to gross necropsy at the end of the observation period. At necropsy, necropsy findings and local tolerance test at the injection site were conducted.
Results : All animals in the 1.0 mL/animal group survived the duration of the study. No CS¥±-YAKCHIM-related effects were evident in clinical signs and body weights in any animal in the 1.0 mL/animal group. At scheduled necropsy, multiple yellow cysts were observed at the injection sites (thigh) of all males and females in the test substance groups. As a result of local tolerance test, there were cysts at the injection sites of all animals that were found with gross findings.
Conclusions : Based on the results of the single intramuscular injection in SD rats, the approximate lethal dose of the CS¥±-YAKCHIM was considered to be greater than 1.0 mL/animal in male and female rats under the conditions of this study.
KEYWORD
¥±-YAKCHIM, pharmacopuncture, toxicity, a single intramuscular injection
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