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KMID : 1146520140150010013
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Journal of the Society of Stroke on Korean Medicine
2014 Volume.15 No. 1 p.13 ~ p.28
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Effects of Schisandra Fructus hexane fraction on high fat diet induced hyperlipidemic mice
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Kim Hyun-Yung
Park Sun-Mi
Kim Young-Kyun
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Abstract
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Objectives: The berries of Schisandra chinensis (Schisandra Fructus) are given the name Omiza in Koreane(五味子), and have been used asremedies for many ailments: to resist infections, increase skin health, and combat insomnia, coughing, and thirst. This study was designed to investigate the effects of Schisandra Fructus hexane fraction (SFH) on serum lipid levels in Hyperlipidemic mice.
Methods: In this experiment, effects on total cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured. And in addition, histopathological and gene expression changes in liver tissue was also observed.
Results: SFH did not affects weight gain, serum AST and ALT in hyperlipidemic mice. Oral administration of SFH lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. Finally, administration of SFH lowered fasting blood glucose significantly. And SFH also ameliorates anti-oxidative stress systems in internal organs which play key role in disease prevention.
Conclusion: Results in our study suggest that SFH can prevent obese through regulation of dyslipidemia and hyperglycaemia.
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KEYWORD
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Schisandra Fructus, hexane fraction, hyperlipidemia
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