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KMID : 1177220060090010011
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Korean Journal of Schizophrenia Research
2006 Volume.9 No. 1 p.11 ~ p.14
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Association between Dysbindin Gene(DTNBP1) and Schizophrenia in Korean Population
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Pae Chi-Un
Jun Tae-Youn
Kim Jung-Jin
Kim Tae-Suk
Lee Chul
Paik In-Ho
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Abstract
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Objectives：Dysbindin (dystrobrevin-binding-protein 1, DTNBP1) gene has been focused due to its possible effect on etiologic mechanism on schizophrenia. Recently, genetic variants of dysbindin gene were investigated in schizophrenia with results of significant association. This study was aimed to examine the association of genetic variants of dysbindin gene with schizophrenia in Korean population.
Methods：Four hundred and seventy four patients with schizophrenia and 478 controls were recruited. Four SNPs of dysbindin gene were examined by pyrosequencing. Haploview 3.2 was used to generate a linkage disequilibrium (LD) map and to test for Hardy- Weinberg (H-W) equilibrium. Tests for associations of multi-marker haplotypes were performed using COCAPHASE v2.403.
Results：Genotypes of all markers were in H-W equilibrium in both patients with schizophrenia and controls. Haplotype analysis revealed a significant association (LRS=48.181, df=11, p=0.000001). Haplotypes 1-1-1-2 and 1-1-2-1 having the strongest protective effect. Major contribution was due to the rs760761 (C/T) and rs2619522 (A/C) haplotypes (LRS=39.652, df=3, p=0.00000001).
Conclusion：This study represents an association of dysbindin gene and schizophrenia in Korean population. Certain haplotypes of dysbindin gene had possible protective effect to schizophrenia.
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KEYWORD
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Schizophrenia, Dysbindin, Single nucleotide polymorphisms, Association, Genotype, Haplotype
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