KMID : 1177220080110010026
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Korean Journal of Schizophrenia Research 2008 Volume.11 No. 1 p.26 ~ p.30
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Comorbid Obsessive Compulsive Disorder in Patients with Schizolphrenia : Prevalence, Clinical Characteristics, and Quality of Life
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Lee Myung-Ji
Jun Ji-Suk Shin Yong-Bum Kang Min-Hee Lee Jung-Sub Bae Jae-Nam Kim Chul-Eung
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Abstract
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Objectives£ºObsessive-compulsive disorder (OCD) have been observed in a substantial proportion of schizophrenia. This study aimed to evaluate the prevalence of obsessive-compulsive disorder in schizophrenia, and the relationship between obsessivecompulsive disorder and severity of psychopathology, depressive symptoms and quality of life in schizophrenia.
Methods£ºWe interviewed 87 patients, diagnosed as schizophrenia and classified patients according to the existence of OCD evaluated by the Structured Clinical Interview for DSM-¥³. And we evaluated the clinical and demographic data. To investigate the interrelationship, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Positive and Negative Symptom Scale (PANSS), Hamilton rating scale for Depression (HRSD), World Health Organization Quality of life-Brief Scale (WHOQOL-BREF) were applied. Independent t-test, Chi-square test were used to compare groups and Pearson¡¯s correlation was used to assess the relationship between Y-BOCS and other clinical rating scales.
Results£ºThe prevalence of OCD in schizophrenia patients was 16.1%. Patients with schizophrenia and obsessive-compulsive disorder had earlier age at onset and higher mean PANSS-general psychopathology and total score than schizophrenia patients without obsessive-compulsive disorder. The compulsive act sub-score of Y-BOCS was significantly correlated with PANSSpositive score in patients with schizophrenia.
Conclusion£ºOCD is relatively frequent in schizophrenia patients and significantly correlated with the severity of psychotic
symptoms.
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KEYWORD
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Obsessive-compulsive disorder, Schizophrenia, Psychopathology, Depression, Quality of life
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