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KMID : 1177220090120020063
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Korean Journal of Schizophrenia Research
2009 Volume.12 No. 2 p.63 ~ p.68
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Polydipsia and Associated Factors is Chronic Schizophrenic Patients
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Kwon Min-Ji
Yim Seon-Jin
Sim Min-Young
Lee Hwang-Bin
Lee Jong-Il
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Abstract
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Objectives：Polydipsia is a condition of consuming excessive amount of liquid (more than 3 l/day). This study is aimed to evaluate the prevalence of polydipsia in chronic schizophrenia patients and the clinical characteristics of patients with polydipsia.
Methods：Eighty-three patients diagnosed with schizophrenia or schizoaffective disorder were included. Body weight was checked twice a day and normalized diurnal weight gain (NDWG) was calculated. Polydipsia was defined as above 2.5% of NDWG. We checked out prolactin level. We compared demographic and clinical characteristics between polydipsia and non-polydipsia groups. Relationships between NDWG and clinical characteristics were also measured.
Results：Among 83 patients, 11 (13.3%) met the polydipsia criteria. There were no significant differences in age, sex, duration of illness, dose and generation of antipsychotics, severity of illness, side effects, and severity of nicotine dependence. After controlling for age and sex, prolactin levels were positively correlated with NDWG. In the regression analysis, prolactin levels were also implicated in NDWG, but not other variables.
Conclusion：Considering the relationship between prolactin level and NDWG, hypothalamic or hippocampus contribution should be considered in pathophysiology of polydipsia.
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KEYWORD
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Polydipsia, Schizophrenia, Prolactin
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