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KMID : 1189220080350040267
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Korean Journal of Reproductive Medicine
2008 Volume.35 No. 4 p.267 ~ p.274
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Association between Endometriosis and Human α2-Heremans Schmidt Glycoprotein (AHSG) Polymorphism
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Kim Jin-Ju
Chae Soo-Jin
Kim Jong-Mee
Lee Gyoung-Hoon
Choi Young-Min
Kim Sung-Hoon
Shin Jung-Ho
Lee Taek-Hoo
Hur Jun-Young
Lee Byung-Seok
Oh Sung-Taek
Lee Kyu-Sup
Lim Young-Taik
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Abstract
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Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in α2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women.
Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis.
Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894).
Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population.
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KEYWORD
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Endometriosis, AHSG, Polymorphism
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