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KMID : 1189220100370010065
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Korean Journal of Reproductive Medicine
2010 Volume.37 No. 1 p.65 ~ p.72
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The optimal time for embryo transfer in fresh in vitro fertilization: Comparison between day 3 and day 5 on pregnancy outcomes
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Lyu Sang-Woo
Yoon Tae-Ki
Kim You-Shin
Kim A-Ri
Lee Woo-Shik
Won Hyung-Jae
Han Ji-Eun
Seok Hyun-Ha
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Abstract
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Objective: To compare the respective pregnancy outcomes of cycles undergoing elective two cleavage-stage embryos transfer (2ET) and three cleavage-stage embryos transfer (3ET) in fresh in vitro fertilization and embryo transfer (IVF-ET) program.
Methods: We conducted a retrospective matched case control study that included 100 women with 2ET and 100 women with 3ET from January 2007 to June 2009. Subjects were matched for reproductive profiles and cycle characteristics. All of transferred embryos in both groups had good qualities. Pregnancy rates (PR), implantation rate, and multiple PR were compared.
Results: Demographics, stimulation parameters and embryological data were comparable in both groups. Main pregnancy outcomes with 2ET and 3ET groups were not statistically different; implantation rate (41.0% vs. 35.3%), positive pregnancy rate (58.0% vs. 60.0%), clinical PR (55.0% vs. 59.0%), ongoing PR (51.0% vs. 55.0%), respectively. However, the 3ET group showed significantly higher multiple pregnancy and triplet pregnancy rates (30.9% vs. 50.8%, p=0.031; 1.8% vs. 11.9%, p=0.036, respectively).
Conclusion: In women with favorable conditions and good quality embryos undergoing IVF, 2ET can get pregnancy outcomes comparable to those of 3ET and reduce multiple pregnancy (especially, triplet pregnancy).
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KEYWORD
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In vitro fertilization, 2 day Embryo transfer, 3 day Embryo transfer, Pregnancy outcome, Multiple pregnancy
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