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KMID : 1189220100370030239
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Korean Journal of Reproductive Medicine
2010 Volume.37 No. 3 p.239 ~ p.244
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Comparison between GnRH Antagonist and Agonist Long Protocols in Poor Responders
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Ku Seung-Yup
Choi Ji-Young
Kim Hoon
Jee Byung-Chul
Suh Chang-Suk
Kim Seok-Hyun
Choi Young-Min
Kim Jung-Gu
Moon Shin-Yong
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Abstract
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Objective: The objective of this retrospective study was to compare the in vitro fertilization (IVF) outcomes of gonadotropin￢releasing hormone (GnRH) agonist and GnRH antagonist protocols in poor responders.
Methods: A total of 172 cycles in subjects with less than 5 oocytes retrieved treated with either GnRH agonist long protocols or antagonist protocols were included. The outcome variables such as numbers of growing follicles and retrieved oocytes, and the fertilization rate were evaluated as the main outcome measures.
Results: There was no difference in regard to the numbers of growing follicles and oocytes, and fertilization rate between the two groups. E2 level on Day 7/8, mean gonadotropin dose, and the days of stimulation were shown to be statistically different (p<0.01, respectively).
Conclusion: Considering that similar results were observed with less time and gonadotropin dose, GnRH antagonist protocol may be considered as a preferable choice over GnRH agonist protocols in poor responders.
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KEYWORD
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Poor responder, Gonadotropin-releasing hormone agonist, GnRH antagonist, Controlled ovarian hyperstimulation, in vitro fertilization
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