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KMID : 1218220110030010034
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Korean Journal of Pediatric Urology
2011 Volume.3 No. 1 p.34 ~ p.38
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The Changes of Antibiotic Sensitivity to the Causative Organisms of Pediatric Urinary Tract Infection by Year: Comparision with Adults
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Kim Soo-Dong
Hur Jun
Cho Won-Yeol
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Abstract
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Purpose: The overuse and misuse of antimicrobial agents have made it more difficult to appropriately select an antibiotics for medical uses. We analyzed annual changes in the antibiotic sensitivities of microorganisms that cause urinary tract infection (UTI) in pediatric and adult patients.
Materials and Methods: We retrospectively analyzed 17,110 uropathogens and their antimicrobial sensitivities from 10,833 patients who were admitted to or visited an out-patient clinic due to UTIs from Jan 2003 to Dec 2008.
Results: The fraction of pediatric UTI cases was 21.0%. The pathogens commonly isolated from pediatric patients were Escherichia coli (30.0%), Enteroccus faecalis (14.0%), Klebsiella pneumoniae (7.4%), and Coaulasenegatve
Staphylococcs (5.8%). In adult patients, E. coli (22.2%), Pseudomonas aeruginosa (9.1%), Enterococcus faecium (8.1%), and Enterocccus faecalis (7.5%) were most commonly recovered. The Enterococcus faecalis infection rate was significantly increased among pediatric patients. Compared to 2003, the rate of E. coli resistance to ciprofloxacin in adult patients increased from 42% to 50% while resistance to levofloxacin increased from 47% to 71%.
Conclusions: E. coli was the most common single organism that caused UTI in children and adults. In pediatric patients, attention should be devoted to increasing rates of infection with Enterococcus faecalis, and other Gram-negative or -positive bacterial pathogens. These findings emphasize that antibiotic treatment modalities, especially empirical therapies, should be based on antimicrobial resistance surveillance studies.
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KEYWORD
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Pediatric, Urinary tract infection, Resistance, Antibiotics
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