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KMID : 1218220110030020047
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Korean Journal of Pediatric Urology
2011 Volume.3 No. 2 p.47 ~ p.51
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Development and Descent of Testis
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Kim Ki-Ho
Jung Yong-Wook
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Abstract
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Embryos with a Y chromosome usually develop testes. The SRY gene on the short arm of the Y chromosome acts as the switch that directs development of the indifferent gonad into a testis. By the eighth week, Leydig cells begin to secrete testosterone, which induce masculine differentiation of the mesonephric ducts and the external genitalia. Mullerian inhibiting substance (MIS) is produced by the Sertoli cells, which suppresses development of the paramesonephric ducts, which form the uterus and uterine tubes. The mesonephric ducts, which drained urine from the mesonephric kidneys, play an essential role in the development of the male reproductive system. Testicular descent is a complex-developmental process involving anatomical and hormonal regulation. Today, testicular descent can generally be accepted as a two-stage model with different anatomy and hormonal regulation. The gubernaculums is an important role of testicular descent, and the active proliferation of the gubernacular tip and cremaster muscle, its rhythmic contraction, as well as the chemotactic gradient provided by the calcitonin gene-related peptide (CGRP) result in eventual migration of the testis into the scrotum.
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KEYWORD
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Testis, Testicular descent, Testicular hormone
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