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KMID : 1218220120040020042
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Korean Journal of Pediatric Urology
2012 Volume.4 No. 2 p.42 ~ p.46
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Testosterone Replacement Therapy in Children
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Lee Sang-Don
Nam Hyung-Jong
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Abstract
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Male hypogonadism is decreased production of testosterone, sperm, or both or, rarely, decreased response to testosterone, resulting in delayed puberty, reproductive insufficiency, or both. It may result from a disorder of the testes (primary hypogonadism) or of the hypothalamic-pituitary axis (secondary hypogonadism). Diagnosis is by measurement of serum testosterone, luteinizing hormone, and follicle-stimulating hormone and by stimulation tests with human chorionic gonadotropin or gonadotropin- releasing hormone. Treatment varies with etiology but typically includes testosterone replacement. Intramuscular administration of long-acting testosterone esters is the most commonly used treatment for male hypogonadism. There are various established guidelines in adulthood for male and female sex hormone replacement treatment, whereas great variability with no consensus exists for the management of children and adolescents.
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KEYWORD
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Hypogonadism, Child, Testosterone
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