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KMID : 1235920090010020167
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Medical Journal of Catholoc University of Daegu
2009 Volume.1 No. 2 p.167 ~ p.174
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Functional Analysis of novel marB gene of Escherichia coli K-12
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Park Byung-Tae
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Abstract
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Antibiotic resistance is often associated with the production of inner membrane proteins (for example, AcrAB/ToIC efflux pump) that are capable of extrude antibiotics, detergents, dyes and organic solvents. In order to evaluate the unknown MarB function of Escherichia coli, especially focused on the function of OmpF porin and ToIC, several mutants were constructed by T4GT7 transduction. MarB protein of E. coli K-12 showed its activity at ToIC protein as target molecule. Some paper reported MarB show decreased MIC through ToIC function. and ToIC regulates OmpF function. By this experiment, MarB could decrease MIC through the ToIC protein as the target molecule.
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KEYWORD
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E. coli, Mar, MarB, OmpF, TolC’Efflux Pump, Resistance
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