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KMID : 1235920090010020181
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Medical Journal of Catholoc University of Daegu
2009 Volume.1 No. 2 p.181 ~ p.187
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Association Between Metabolic Syndrome, Microalbuminuria and Serum Cystatin C in Type 2 Diabetic Patients
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Lee Ji-Hyun
Kim Hyun-Sook
Sohn Ho-Sang
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Abstract
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Background: The aim of study was to analyze correlations between metabolic syndrome, microalbuminuria and
serum cystatin C in type 2 diabetic patients.
Material and Methods: Total 113 type 2 diabetic patients are included in this study. Metabolic syndrome was defined by the NCEP-ATP III criteria, but abdominal obesity was defined as waist ≥90 cm in man, waist ≥85 cm in women. Serum cystatin C was measured from fasting serum sample and urine albumin excretion was measured from 24-hours urine collection.
Results: Microalbuminuria was detected in 26.5% and metabolic syndrome was detected in 31.9%. The serum
cystatin C level and prevalence of microalbuminuira were significantly higher in patients with metabolic syndrome. In multiple logistic regression analysis for microalbuminuria, waist circumference and diabetic duration were independent variables. In stepwise multiple regression analysis for serum cystatin C, age, creatinine and urine albumin excretion were independent variables.
Conclusions: In type 2 diabetic patients, serum cystatin C was higher in metabolic syndrome and positively
correlated with urine albumin excretion. We suggest serum cystatin C and microalbuminuria may be markers of metabolic syndrome in type 2 diabetic patients.
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KEYWORD
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Cystatic C, Diabetes mellitus, Metabolic syndrome, Microalbuminuria
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