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KMID : 1235920100020010001
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Medical Journal of Catholoc University of Daegu
2010 Volume.2 No. 1 p.1 ~ p.8
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Diagnosis and Pharmacologic Therapy for Neuropathic Pain
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Lee Dong-Kuck
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Abstract
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Neuropathic pain (NP) disorders are etiologically heterogenous and relatively uncommon consequences of injury to or disease of the nervous system. NP has gained increased attention from clinicians and scientists as a result of a better understanding of underlying mechanism and development of proved analgesic therapies. The available pharmacological therapies offer palliative symptom control but are not curative. Tricyclic antidepressants have multiple potentially analgesic actions and were the first drugs to be proved via randomized clinical trials. Some of the newer pharmacological agents, including those in the anticonvulsant category, have a more favourable side effect profile and have achieved widespread acceptance. Outside the antidepressant and anticonvulsant categories, the ease of use of topical agents makes them appropriate as a first therapeutic step in patients with postherpetic neuralgia. For opioids, efficacy in a high proportion of patients across the full span of NP disorders makes them another first-line option. More specific evidence-based guidelines await a more complete clinical trials data-set.
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KEYWORD
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Neuropathic pain, Pharmacologic therapy
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