KMID : 1235920100020010017
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Medical Journal of Catholoc University of Daegu 2010 Volume.2 No. 1 p.17 ~ p.20
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Gene therapy for treating liver fibrosis
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Kim Kyung-Hyun
Park Kwan-Kyu
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Abstract
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Liver fibrosis is a wound-healing process after chronic liver injury, and characterized by the activation of hepatic stellate cells and excess production of extracellular matrix components. In response to various insults, such as alcohol, hepatotoxin, hepatocyte damage will cause the release of cytokines, chemokines and reactive oxygen species. To modulate the interation of these molecules, various molecular therapeutic approaches were developed to directly address hepatic injury and fibrosis. Gene therapy is the insertion or deletion of genes into an individual¡¯s cell and biological tissues to treat disease. This article intends to provide an update in terms of the current status of gene therapy based on oligodeoxynucleotides for hepatic fibrosis and how far we are from clinical utilization of these new therapeutic modalities.
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KEYWORD
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Liver fibrosis, Gene therapy, Oligodeoxynucleotides
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