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KMID : 1235920110030010072
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Medical Journal of Catholoc University of Daegu
2011 Volume.3 No. 1 p.72 ~ p.76
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2 Case reports of Bisphosphonate-related osteonecrosis of the jaw (BRONJ) on mandible
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Park In-Sook
Lee Ju-Hyoung
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Abstract
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Bisphosphonates are drugs used for osteoporosis, metastatic bone diseases, Paget’s disease and multiple myeloma.
These drugs have high affinity on bone remodeling site and inhibit bone resorption. Since bisphosphonates have long
half-reduction time, they accumulate at bone and act for a long time. Recently, jaw bone necrosis was reported in some patients who have taken bisphosphonates for osteoporosis or other bone disease. It is called Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ). It can appear after oral surgery, especially extraction of teeth or surgery of implantation. In two female patients with osteoporosis taking bisphosphonates for a long time, osteonecrotic mandibular lesions occurred after extraction of teeth. We successfully treated two patients using both surgical methods and conservative management.
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KEYWORD
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Bisphosphonate, BRONJ, Osteonecrosis, Osteoporos
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