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KMID : 1235920120040010011
Medical Journal of Catholoc University of Daegu
2012 Volume.4 No. 1 p.11 ~ p.15
Relation between the Frequency of Cerebral Atherosclerosis and Stroke Risk Factors in Patients with Extracranial Carotid Disease
Kwon Doo-Hyuk

Do Jin-Kuk
Abstract
Purpose: In Korean patients, atherosclerotic lesions are more often found in the intracranial rather than in the
extracranial cerebral arteries compared to Caucasian patients. However, extracranial carotid artery lesions are
increasingly recognized in recent years. The aim of this investigation was to determine the frequency of combined
intracranial atherosclerotic lesions in patients with extracranial carotid disease and to analyze the differences in stroke
risk factors between patients with pure extracranial carotid artery disease and those who have combined extra- and
intracranial artery disease.

Materials and Methods: We reviewed 50 consecutive patients with extracranial carotid artery stenosis (defined as
>50% narrowing of diameter) or occlusion proven by a conventional angiography. We investigated the distribution of
atherosclerotic lesions and compared risk factors for atherosclerosis between the pure extracranial carotid occlusive
group and the combined extra- and intracranial artery occlusive group.

Results: Among 50 patients with extracranial carotid occlusive lesions, combined intracranial stenosis (>50%
narrowing of diameter) or occlusion was seen in 23 patients. Multivariate analysis showed that diabetes mellitus was
the only factor that was associated with the combined extra- and intracranial artery occlusive groups (p<0.05).

Conclusion: The combined extra- and intracranial atherosclerotic lesions were frequently seen in Korean patients. Diabetes mellitus may play an important role in the development of intracranial atherosclerosis in patients who have combined extra- and intracranial occlusive disease.
KEYWORD
Cerebral and carotid artery diseases, Angiography, Stroke risk factors
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