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KMID : 0032220240360020091
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Annals of Dermatology
2024 Volume.36 No. 2 p.91 ~ p.98
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Factors Associated With Achieving Complete Skin Clearance Compared to Almost Complete Skin Clearance in Patients With Moderate to Severe Psoriasis Treated With Biologics: A Retrospective Chart Review
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Hong Eun-Ji
Yoon Hee-Jung
Kwon Min-Jung
Kim Jae-Yun
Kim Jung-Eun
Park Young-Lip
Lee Sang-Hoon
Bae You-In
Lee Sul-Hee
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Abstract
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Background: Biologics have demonstrated high efficacy in achieving ‘almost complete’ skin clearance in patients with moderate to severe psoriasis. Nonetheless, achieving ‘complete’ skin clearance remains a treatment goal for some highly biologics-resistant patients, as residual lesions impact their quality of life.
Objective: The risk factors for failure to achieve a Psoriasis Area and Severity Index (PASI) 100 response in patients with good response to biologics remain unknown.
Methods: This retrospective study evaluated the risk factors by comparing patients who achieved complete skin clearance (PASI100) with those who achieved almost complete skin clearance (PASI90). A database of 131 psoriasis patients treated with biologics, who achieved a PASI90 or PASI100 response, was reviewed from a tertiar y referral hospital in South Korea. The patients were classified into PASI90 and PASI100 groups according to their PASI response.
Results: The PASI100 group had a lower prevalence of smoking histor y (adjusted odds ratio [OR], 0.34; 95% confidence inter val [CI], 0.14?0.85; p=0.021) and psoriasis on the anterior lower legs at baseline (adjusted OR, 0.18; 95% CI, 0.03?0.99; p=0.049) than patients in the PASI90 group.
Conclusion: This study suggested that smoking histor y and psoriatic skin lesions on the ante- rior lower legs are considered as the risk factors for the failure to achieve a PASI100 response in psoriasis patients treated with biologics.
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KEYWORD
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Biologics, Psoriasis, Risk factors
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