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KMID : 0032220240360020112
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Annals of Dermatology
2024 Volume.36 No. 2 p.112 ~ p.118
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Risk of Developing Hypertension in Atopic Dermatitis Patients Receiving Long-term and Low-dose Cyclosporine: A Nationwide Population-based Cohort Study
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Woo Yu-Ri
Choi A-Rum
Song Seo-Won
Kim Su-Yeun
Son Sang-Wook
Cho Sang-Hyun
Kim Suk-Il
Kim Jung-Eun
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Abstract
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Background: Cyclosporine (CS) is a first-line immunosuppressive agent used to manage mod- erate to severe atopic dermatitis (AD). To date, the risk of developing hypertension associated with the long-term use of low-dose CS in AD patients is understudied.
Objective: To determine the cumulative dose-dependent effect of CS on the risk of developing hypertension in patients with AD.
Methods: A nationwide population-based retrospective cohort with 1,844,009 AD patients was built from the Korean National Health Insurance System database from 2005 to 2009.
A Cox proportional-hazard regression analysis was performed according to patients’ CS treatment histor y adjusted for potential confounders.
Results: Current use of CS was associated with an increased risk of developing hypertension (adjusted hazard ratio, 4.442; 95% confidence inter val, 3.761?5.247). Among the current CS users, a higher cumulative dose of CS (≥39,725 mg) or longer cumulative use of CS (≥182 days), was significantly associated with an increased risk of developing hypertension.
Conclusion: The incidence of CS-associated hypertension is ver y low when using low-dose treatment regimens for AD.
However, the current use or a high cumulative dose of CS for treating patients with AD increases the risk of developing hypertension. Precaution is needed when prescribing CS for long-term treatment of AD.
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KEYWORD
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Atopic dermatitis, Cyclosporine, Dose-response relationship, drug, Hypertension, Risk
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