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KMID : 0043319830060020103
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Archives of Pharmacal Research
1983 Volume.6 No. 2 p.103 ~ p.108
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Determination of Sulfur-containing Drugs by Gas Chromatography with Flame Photometric Detector
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Kim KH
Cho YH/Park MK/Lee WK
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Abstract
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Such sulfur-containing drugs as chlorpromazine, sulfonamides and thiazides were determined by gas chromatograghy with flame photometric detector (FPD) and flame ionization detector (FID). 0.6% QF-1 or 3% SE-30 on Chromosorb WAWDMCS were found suitable for drugs listed above. In the experimental conditions given maximum response the FPD response and the response ratio of FPD increased with the number of sulfur atom per molecule. It was possible to obtain a linear calibration curve from 10-9 mole to 2 X 10-8 mole and to analyze variety of sulfur drugs by the calibration curve of one sulfur standard.
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