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KMID : 0043319840070010023
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Archives of Pharmacal Research
1984 Volume.7 No. 1 p.23 ~ p.31
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Multicomponent Analysis of Metabloites of Low Volatility in Biological Fluids by Field Ionization Mass Spectrometry
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Kim KR
Anbar M
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Abstract
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An improved mass spectrometric method for multicomponent analysis of metabolites in urine, well-suited for clinical biochemistry, is described. The method involves solvent elution of the metabolites from an adsorbent and the concentration of the eluate on a microadsorption column. This is administered by a direct inlet probe into the ionizing source of field ionization mass spectrometry (FIMS), which yield a molecular weight profile of the metabolites. The procedure provides rapidly (within one hour) reproducible profiles from a small volume of urine. The optimization of the sampling technique and the reproducibility are discussed.
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KEYWORD
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